T cell subsets in experimental lupus nephritis: modulation by bacterial superantigen

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T cell subsets in experimental lupus nephritis: modulation by bacterial superantigen.

Chronic graft-vs-host disease (GvH), induced by injection of DBA/2 lymphocytes into (C57BL/6 x DBA/2)F1 hybrids, is a murine model for lupus nephritis, associated with a Th2-dependent polyclonal B cell activation. The development of glomerulosclerosis in this model is preceded by a glomerular influx of LFA-1+ T cells. We investigated whether exposure to bacterial superantigen would modulate the...

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The effects of biweekly intravenous injections of Staphylococcus Enterotoxin B (SEB) into autoimmune MRL-lpr/lpr (MRL/lpr) mice were investigated. Rather than causing the expansion of V beta 8+ T cells, SEB administration resulted in the reduction V beta 8+, CD4-CD8- "double-negative" (DN) T cells. This was shown by FACS analysis as this putative pathogenic population was diminished in both spl...

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ژورنال

عنوان ژورنال: Nephrology Dialysis Transplantation

سال: 1999

ISSN: 1460-2385

DOI: 10.1093/ndt/14.suppl_1.14